Millions of Americans already trust cannabis as part of their wellness routines. As we’ve shared before, certain cannabis compounds—specifically the cannabinoid CBD—are often discussed for their potential to support mood and emotional well-being. Studies suggest that CBD may influence stress responses, but individual experiences can vary.
While this is important, it doesn’t explain exactly how CBD interacts with our body’s natural systems. Part of the answer may lie in the ways that CBD interacts with hormones like cortisol, sometimes referred to as the "stress hormone.”
In today’s post, we’ll take a closer look at hormones and cannabinoids. We’ll also explore the endocannabinoid system to better understand how these plant compounds and our bodies might interact in the context of general wellness.
Cannabis for Wellness: The CBD vs THC Question
As you may know, CBD is one of the major cannabinoids found in the cannabis plant. Current research is investigating CBD’s potential for a wide variety of applications, such as general comfort and supporting restful nights, among others.
Another principal cannabinoid is THC, which is different than CBD in several ways. For example, THC can impart an intoxicating experience. When it comes to cannabis and wellness, especially in situations involving stress, THC may influence feelings and mood differently depending on the individual and the amount used.
According to a large-scale review of available literature, THC’s effects are highly dose-dependent. At low doses, some users report mood-related effects, but at higher doses, THC may produce different responses including those related to discomfort or anxiety. This is why the approach of “start low and go slow” is commonly recommended for finding the optimal amount for your body.
CBD tends to be described as non-intoxicating and is often explored for how it may support general wellness. Some research looks at how CBD and THC might interact together, with CBD potentially influencing the experience of THC.
Cannabis for Wellness: CBD, Cortisol, and the Stress Response
People are turning to wellness supplements more often than ever before, and the American Psychological Association has labeled stress a national mental health concern.

How does cortisol fit into the picture?
Cortisol is commonly called “the stress hormone,” but it also has other important roles, such as regulating blood sugar and supporting metabolic function. When the body experiences an excess of cortisol—typically from a stressful situation, emotional episode, or intense exercise—it can contribute to changes in blood pressure, metabolism, and overall wellness.
Initial research suggests that CBD may influence cortisol levels in the body, although more studies are needed. One clinical study showed changes in blood cortisol levels in participants taking CBD, but findings on how this affects mood and wellness are still under investigation.
CBD and High Intensity Workouts
High intensity workouts (working at 80-90% of your maximum heart rate) remain popular in fitness circles, but many experts agree that they should be done in moderation. While pushing our bodies can feel rewarding, increased cortisol can result from intense activity. This may affect your workout goals and overall balance.

Cortisol’s function is to spur the body into producing more energy in moments of stress or exertion; when we deliberately engage in intense exercise, our bodies may break down muscle tissue to extract energy in the form of sugar. Extended periods of high cortisol can influence muscle and weight goals. Day-to-day demands and high-intensity exercise are just some factors that may influence cortisol levels.
Since embracing wellness is a core value at Papa & Barkley, we encourage you to get the most out of both your wellness products and your workout routine. Remember that moderation is key, and consider exercise routines that are gentle and measured. For those days when you go the extra mile, many people choose to include plant-based products in their post-workout regimen.
CBD for Health and Wellness: In Conclusion
We’re passionate about our customers’ health and overall wellness and the possibilities offered by this all-natural plant. If you have other questions about supporting your wellness routine, reach out. We’re always here to answer questions!